Application of biomarkers in the assessment and treatment of cancer-related fatigue

Abstract Cancer-related fatigue (CRF) is a common side effect experienced by cancer patients and disease-free survivors, significantly impacting their quality of life. This review summarizes the application of biomarkers in assessment and treatment of CRF, while exploring its biological basis through inflammatory pathways, neuroendocrine responses, metabolic disorders, mitochondrial dysfunction, and oxidative stress. Furthermore, the paper discusses the potential and value of biomarkers in CRF management, including therapeutic approaches such as psychostimulants, corticosteroids, nutritional supplements, and exercise interventions. The development of biomarkers offers a new perspective for the early identification, diagnosis, and treatment of CRF.