Identification and validation of serum amino acids as diagnostic biomarkers for diabetic peripheral neuropathy
This study successfully identified and validated the metabolomic significance of arginine, tyrosine, and glutamic acid as potential biomarkers for diagnosing DPN. These findings are particularly valuable, as they establish a foundational step toward developing the first routine laboratory test for DPN. Moreover, the diagnostic model that was constructed in this study effectively distinguishes DPN patients from those with T2DM without neuropathy, thereby potentially facilitating early diagnosis and intervention.
Authors
- Weisheng Xu (ORCID: https://orcid.org/0000-0002-8044-7034)
- Jiang He (ORCID: https://orcid.org/0000-0002-8286-9652)
- Qingqing Wang (ORCID: https://orcid.org/0000-0002-5846-2801)
- Jiying Wang (ORCID: https://orcid.org/0000-0003-0005-4386)
- Shiyu Sun (ORCID: https://orcid.org/0000-0002-4036-8921)
- Fuqing Lin (ORCID: https://orcid.org/0000-0002-0838-7321)
- Tong Jin (ORCID: https://orcid.org/0000-0002-9644-1753)
- Huan Xing (ORCID: https://orcid.org/0009-0004-1127-0476)
- Y. Kan
- Qi Hui
Institutions
- Tongji University (CN)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-06-13
- DOI
- https://doi.org/10.4239/wjd.v16.i6.105592
- Citations
- 3
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49