Analysis of serum S100A12, soluble advanced glycation end products receptor, and gut microbiome in elderly patients with colorectal cancer
Elevated serum S100A12 and sRAGE in elderly patients with CRC reflected gut microbiome dysbiosis and systemic inflammation, driven by IL-6/TNF-α signaling. Their post-chemotherapy decline parallels microbiota restoration, supporting a microbiome-inflammation-biomarker axis. The combined biomarker model offers robust clinical utility for chemotherapy efficacy prediction and personalized therapeutic strategies.
Authors
- Long Jiang Zhang (ORCID: https://orcid.org/0000-0002-6664-7224)
- Weitao Liang
- Yingkun Zhu (ORCID: https://orcid.org/0000-0002-9025-8800)
- Xiang Chen (ORCID: https://orcid.org/0000-0001-7318-0274)
- Shi-Xing Qiao (ORCID: https://orcid.org/0000-0002-2808-6243)
- Mingliao Niu
Institutions
- Henan University of Traditional Chinese Medicine (CN)
- Zhengzhou City Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.4251/wjgo.v17.i6.106393
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81