Metabolic Dysfunction-associated Steatotic Liver Disease Alters Fatty Acid Profiles in the Liver and Adipose Tissue
Patients with MASH exhibited reduced hepatic PUFA content, increased hepatic saturated FAs, and a higher n6-to-n3 PUFA ratio, whereas no clear trends were observed in adipose tissue. These findings highlight distinct differences in FA metabolism between the liver and adipose tissue in MASLD, emphasizing tissue-specific regulatory mechanisms.
Authors
- Ursula Schwab (ORCID: https://orcid.org/0000-0003-1838-7525)
- Pirjo Käkelä (ORCID: https://orcid.org/0000-0002-6383-0779)
- Ville Männistö (ORCID: https://orcid.org/0000-0002-0735-400X)
- Jussi Pihlajamäki (ORCID: https://orcid.org/0000-0002-6241-6859)
- Kirsi A. Virtanen (ORCID: https://orcid.org/0000-0001-6183-4525)
- Vesa Kärjä
- Dorota Kamińska (ORCID: https://orcid.org/0000-0003-1829-576X)
- Saana Palomurto (ORCID: https://orcid.org/0000-0001-6373-8932)
Institutions
- University of California, Los Angeles (US)
- University of Eastern Finland (FI)
- Turku University Hospital (FI)
- Kuopio University Hospital (FI)
- Turku PET Centre (FI)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1210/clinem/dgaf346
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Itä-Suomen Yliopisto
- Suomen Lääketieteen Säätiö
- Mary och Georg C. Ehrnrooths Stiftelse
- Suomen Kulttuurirahasto
- Kuopion Yliopistollinen Sairaala
- Sigrid Juséliuksen Säätiö
- Diabetestutkimussäätiö