Clinical and Genetic Characteristics of Adult Nonautoimmune Hypothyroidism: A Single-institution Study
In patients with treatment-naive adult nonautoimmune hypothyroidism, thyroid dysfunction was milder and thyroid volume was smaller than in patients with autoimmune hypothyroidism. Mendelian forms were rare, but the unexpectedly high frequency of monoallelic variant carriers suggests that these variants may confer genetic risk for nonautoimmune hypothyroidism.
Authors
- Ai Yoshihara (ORCID: https://orcid.org/0000-0003-1323-4722)
- Chiho Sugisawa (ORCID: https://orcid.org/0000-0003-1685-6201)
- Kiminori Sugino (ORCID: https://orcid.org/0000-0002-9692-9871)
- Matsuo Taniyama (ORCID: https://orcid.org/0009-0003-7287-2297)
- Natsuko Watanabe (ORCID: https://orcid.org/0000-0003-2297-5004)
- Nami Suzuki (ORCID: https://orcid.org/0000-0003-2877-6647)
- Hidemi Ohye
- Miho Fukushita (ORCID: https://orcid.org/0000-0001-6815-5891)
- Satoshi Narumi (ORCID: https://orcid.org/0000-0002-0940-4517)
- Erika Uehara (ORCID: https://orcid.org/0000-0001-8248-1845)
- Kanako Tanase‐Nakao (ORCID: https://orcid.org/0009-0008-6823-9938)
- Jaeduk Yoshimura Noh (ORCID: https://orcid.org/0000-0001-7340-8603)
- Fumiko Otsuka (ORCID: https://orcid.org/0000-0002-7190-7799)
- Kosuke Inoue (ORCID: https://orcid.org/0000-0001-9614-8103)
- Koichi Ito (ORCID: https://orcid.org/0000-0001-6995-1056)
- Tatsuya Iida (ORCID: https://orcid.org/0009-0005-0821-0648)
- Masako Matsumoto
Institutions
- Keio University (JP)
- Kyoto University (JP)
- Noguchi Thyroid Clinic and Hospital Foundation (JP)
- Ito Hospital (JP)
- National Center For Child Health and Development (JP)
- SHOWA Medical University Fujigaoka Hospital (JP)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1210/clinem/dgaf352
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00