Molecular Dynamics Simulations of a Putative Novel Mechanism for <scp>UCP1</scp>‐Assisted <scp>FA</scp> Anion Transport
We provide a novel, detailed mechanism by which UCP1 facilitates fatty acid anion transport, as part of the fatty acid cycling process originally proposed by Skulachev. The residues involved in this transport are conserved in other SLC25 proteins, suggesting the mechanism may extend beyond UCP1 to other members of the superfamily.
Authors
- Saša Vojvodić
- Mario Vazdar (ORCID: https://orcid.org/0000-0001-6905-6174)
- Elena E. Pohl (ORCID: https://orcid.org/0000-0002-0604-5950)
- Giorgia Roticiani
Institutions
- University of Veterinary Medicine Vienna (AT)
- University of Chemistry and Technology, Prague (CZ)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1111/apha.70068
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- European Commission
- Veterinärmedizinische Universität Wien
- Horizon 2020 Framework Programme
- H2020 Marie Skłodowska-Curie Actions