An enzymatic process of the Morita–Baylis–Hillman (MBH) reaction in a microflow system
A green and efficient method for the Morita-Baylis-Hillman (MBH) reaction has been developed in a microflow system. A Novozym 435-catalyzed MBH reaction is reported, wherein the co-catalyst nicotinamide was employed to enhance the catalytic efficiency. The reaction was carried out under mild conditions, yielding the target product in up to 67% yield within 16 minutes. Although enantioselectivity was not observed with Novozym 435, this method provides an industrially relevant, practical, and efficient recyclable strategy, in which lipase replaces chemical catalysts, and a scale-up experiment was successfully completed in a microflow system.
Authors
- Zheng Fang (ORCID: https://orcid.org/0000-0002-3209-4713)
- Zhao Yang (ORCID: https://orcid.org/0000-0002-7903-9033)
- Yuguang Li (ORCID: https://orcid.org/0000-0002-8927-3536)
- Chengkou Liu (ORCID: https://orcid.org/0000-0001-8610-3956)
- Shuzhan Wang (ORCID: https://orcid.org/0000-0002-5663-9992)
- Rui Zhang (ORCID: https://orcid.org/0000-0003-1370-8289)
- Qianxi Zhou
- Hong Qin (ORCID: https://orcid.org/0009-0006-5607-0712)
- Yujing Hu (ORCID: https://orcid.org/0000-0001-8139-7676)
Institutions
- Nanjing Tech University (CN)
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00884k
- Citations
- 1
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 0.67