Cardiovascular disease and depression as mediators between red blood cell distribution width to albumin ratio and cognitive impairment in older adults
RAR is significantly associated with cognitive impairment, with a stronger association when RAR ≥3.2. CVD and depression partially mediate this relationship, suggesting RAR as a potential biomarker for cognitive impairment in older adults.
Authors
- Xinyu Bai
- Jianming Guo (ORCID: https://orcid.org/0000-0002-4343-8622)
- Yongquan Gu (ORCID: https://orcid.org/0000-0002-2869-9736)
- Dikang Pan (ORCID: https://orcid.org/0000-0001-8603-353X)
- Hui Wang (ORCID: https://orcid.org/0000-0002-8574-824X)
- Sensen Wu (ORCID: https://orcid.org/0000-0001-8304-8998)
- Cong Wang (ORCID: https://orcid.org/0000-0002-2236-4636)
- Peng Yu (ORCID: https://orcid.org/0009-0008-0345-5787)
- Lianrui Guo
Institutions
- Capital Medical University (CN)
- Second Affiliated Hospital of Jilin University (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3389/fphys.2025.1587635
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00