OTUD1 exacerbates sepsis-associated encephalopathy by promoting HK2 mitochondrial release to drive microglia pyroptosis
In SAE, OTUD1 deubiquitinates HK2, promoting its dissociation from mitochondria, which triggers microglia pyroptosis, leading to neuronal damage and cognitive impairment.
Authors
- Xuemin Song (ORCID: https://orcid.org/0000-0002-1887-8386)
- Hailong Gong (ORCID: https://orcid.org/0000-0001-7004-8542)
- Die Wu (ORCID: https://orcid.org/0009-0008-3223-801X)
- Guoqing Jing (ORCID: https://orcid.org/0000-0002-8084-4689)
- Yun Xia (ORCID: https://orcid.org/0000-0003-2184-4870)
- Han Wang (ORCID: https://orcid.org/0000-0002-1253-5972)
- Xing Wang (ORCID: https://orcid.org/0000-0003-4682-5780)
- Tongtong Du
- Huifan Liu
- Wanhong Liu (ORCID: https://orcid.org/0000-0003-3271-4342)
- Min Yuan (ORCID: https://orcid.org/0009-0005-3276-2151)
- Jing Zuo (ORCID: https://orcid.org/0000-0003-3451-2365)
- Xiaojing Wu (ORCID: https://orcid.org/0000-0002-6287-6812)
Institutions
- Peking University (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Peking University People's Hospital (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s12974-025-03480-w
- Citations
- 11
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hubei Province