In vivo RNA-seq and infection model reveal the different infection and immune characteristics of B. pertussis strains in China
The emerging pertussis strains exhibit different colonization advantages in the trachea or lungs, which will influence the transmission patterns of the clinical strains. The tracheal colonization advantage of the partial pertactin-deficient strain may be associated with the overexpression of the <i>relA</i> and <i>sodA in vivo</i> infection.
Authors
- Weilun Zuo
- Meiyan He
- Na Gao (ORCID: https://orcid.org/0000-0002-1831-8354)
- Jiangli Liang
- Wei Chen (ORCID: https://orcid.org/0000-0002-6989-9830)
- Mengyao Zhang (ORCID: https://orcid.org/0009-0004-0733-2793)
- Li Shi (ORCID: https://orcid.org/0000-0001-9508-7863)
- Qin Gu (ORCID: https://orcid.org/0000-0002-3722-6375)
- Yan Huang
- Yan Ma
- Jingyan Li (ORCID: https://orcid.org/0000-0003-4464-9461)
- Xiao Ma (ORCID: https://orcid.org/0000-0002-6594-0613)
- Mingbo Sun
- Shuyuan Liu (ORCID: https://orcid.org/0000-0002-2488-8193)
Institutions
- Xiamen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Medical Products Administration (CN)
- Kunming Medical University (CN)
- Second Affiliated Hospital of Kunming Medical College (CN)
- The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3389/fcimb.2025.1547751
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Yunnan Provincial Science and Technology Department