Neuroprotective potential of quercetin in Alzheimer’s disease: targeting oxidative stress, mitochondrial dysfunction, and amyloid-β aggregation
These findings suggest that quercetin confers neuroprotection by targeting multiple pathological mechanisms involved in AD, including oxidative stress, mitochondrial dysfunction, AChE activity and Aβ aggregation. Quercetin demonstrates promise as a natural therapeutic agent for the treatment of AD. However, further <i>in-vivo</i> investigations and clinical studies are warranted to validate these findings and explore its translational potential.
Authors
- Riadh Badraoui (ORCID: https://orcid.org/0000-0001-9054-7744)
- Fevzi Bardakçi (ORCID: https://orcid.org/0000-0003-3377-2763)
- Malvi Surti (ORCID: https://orcid.org/0000-0002-7609-3026)
- Mohd Adnan (ORCID: https://orcid.org/0000-0002-7080-6822)
- Arif Jamal Siddiqui (ORCID: https://orcid.org/0000-0002-6236-0920)
- Mitesh B. Patel (ORCID: https://orcid.org/0000-0002-9283-2124)
Institutions
- University of Ha'il (SA)
- King Salman Center for Disability Research (SA)
- Parul University (IN)
- Parul University (IN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3389/fphar.2025.1593264
- Citations
- 14
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 19.52
Funders
- King Salman Center for Disability Research