Veillonella parvula outer membrane vesicles increase ICAM-1+ neutrophils exhibiting elevated NET formation via ROS–PAD4 signaling
<i>V. parvula</i> OMVs were initially found to increase the population of ICAM-1<sup>+</sup> neutrophils, which subsequently exhibited elevated NET formation via the ROS-PAD4 signaling pathway. This study elucidates a novel pathogenic mechanism of <i>V. parvula</i> OMVs and highlights the potential of targeting ICAM-1<sup>+</sup> neutrophils as a therapeutic approach for chronic periodontitis.
Authors
- Wei Zhou (ORCID: https://orcid.org/0000-0001-7467-3628)
- Jiabao Zhuang (ORCID: https://orcid.org/0000-0002-6762-6273)
- Teng Li (ORCID: https://orcid.org/0000-0003-1332-2140)
- Yiting Jiang (ORCID: https://orcid.org/0009-0009-4063-4992)
- Xia Zhao
- Lina Xu (ORCID: https://orcid.org/0000-0003-1785-382X)
- Zhiyan He (ORCID: https://orcid.org/0000-0002-6242-6563)
- Zhongchen Song
- Huiwen Chen
Institutions
- Shanghai Jiao Tong University (CN)
- Wenzhou Medical University (CN)
- Shanghai Ninth People's Hospital (CN)
- Zhejiang Taizhou Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3389/fcimb.2025.1540634
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University