Utilization of artificial circular RNAs as miRNA sponges and anti-PD-1 scFv expression platforms to suppress hepatocellular carcinoma progression
Our findings highlight the potential of artificial circRNAs as a novel therapeutic strategy for HCC. By harnessing their ability to act as miRNA sponges and to express immunomodulatory proteins, these engineered circRNAs offer a promising approach to overcome the challenges associated with HCC therapy.
Authors
- Niangmei Cheng
- Yongping Lai (ORCID: https://orcid.org/0009-0001-3468-3685)
- Jui‐Hung Weng (ORCID: https://orcid.org/0000-0002-0432-3515)
- Bixing Zhao (ORCID: https://orcid.org/0000-0002-0055-3989)
- Yongyi Zeng (ORCID: https://orcid.org/0000-0001-8823-698X)
- Yingying Li (ORCID: https://orcid.org/0000-0003-3243-1975)
- Fei Wang (ORCID: https://orcid.org/0000-0001-8908-5618)
- Liqiong Cai (ORCID: https://orcid.org/0000-0001-6910-4586)
- Cai Guang
- Feifan Cai
Institutions
- Fujian Medical University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1609165
- Citations
- 6
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.84