Polymethoxyflavones extracted from Bauhinia championii alleviate LPS-induced acute lung injury by ameliorating endoplasmic reticulum stress
PMFs inhibited the expression of inflammatory cytokines and reduced oxidative stress injury to resist apoptosis in lung. Moreover, PMFs attenuated LPS-induced ER stress activation by regulating ER stress related targets, which in turn alleviated ALI.
Authors
- Xiaolan Yang (ORCID: https://orcid.org/0000-0002-6903-5995)
- Junsong Jing
- Wenjing Ye (ORCID: https://orcid.org/0000-0003-1001-8880)
- Yuanyuan Li (ORCID: https://orcid.org/0000-0003-0852-8558)
- Sheng Zhang (ORCID: https://orcid.org/0000-0003-0843-0622)
- Zhenqiang You (ORCID: https://orcid.org/0000-0002-4167-6598)
- Ranran Chen (ORCID: https://orcid.org/0000-0003-3216-2373)
- Lianhao Wu
- Jing Shi (ORCID: https://orcid.org/0000-0003-4807-9910)
Institutions
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3389/fphar.2025.1544916
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fujian University of Traditional Chinese Medicine
- Department of Education of Zhejiang Province