Impact of β3-adrenergic receptor agonist on tumor progression and metastasis in renal cell carcinoma models
The β3-AR agonist increases PAT browning, initially promoting primary tumor progression and possibly contributing to tumor initiation, but eventually inducing immune tolerance, leading to anticancer effects on primary tumors. Effects on lung metastases differed from those on primary tumors.
Authors
- Jongchan Kim (ORCID: https://orcid.org/0000-0002-0022-6689)
- Minsun Jung (ORCID: https://orcid.org/0000-0002-8701-4282)
- Won Sik Jang (ORCID: https://orcid.org/0000-0002-9082-0381)
- Jee Soo Park (ORCID: https://orcid.org/0000-0001-9976-6599)
- Won Sik Ham (ORCID: https://orcid.org/0000-0003-2246-8838)
- Myung Eun Lee
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
- Yonsei University Health System (KR)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s12935-025-03834-7
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea