Alterations in peripheral blood immune cell profiles of neuromyelitis optica spectrum disorder across different phases and after B cell depletion therapy
Peripheral blood immune cell profiles of acute NMOSD patients showed widespread distinctions compared to those of remission NMOSD patients, acute MS patients, acute MOGAD patients, and controls, as well as after differential therapies. Our findings provide clues to comprehensively understand the abnormality of the dynamic and integrated immune network in NMOSD, distinguish NMOSD from MS and MOGAD, and search for more effective and safe therapeutic targets.
Authors
- Zhen Jia
- Ruoyi Guo (ORCID: https://orcid.org/0000-0002-7901-8427)
- Zhichao Yao (ORCID: https://orcid.org/0000-0001-5532-5767)
- Xiujuan Song (ORCID: https://orcid.org/0000-0002-7800-6256)
- Lu Liu (ORCID: https://orcid.org/0000-0003-2683-7215)
- Bin Li (ORCID: https://orcid.org/0000-0002-8607-8874)
- Xuying Wang (ORCID: https://orcid.org/0009-0005-9755-4628)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Baoding People's Hospital (CN)
- Baoding No.1 Central Hospital
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1556259
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47