Prognostic and immunological implications of cathepsin Z overexpression in prostate cancer
Our study highlights CTSZ as a potential prognostic and therapeutic biomarker in PCa, demonstrating that its overexpression is associated with immune cell infiltration, immune checkpoint molecule expression (such as PD-1 and PD-L1), tumor mutation burden, and key oncogenic pathways. These findings suggest that CTSZ may serve not only as a predictor of patient prognosis but also as a promising indicator for immunotherapy response and personalized treatment strategies in PCa.
Authors
- Zongyao Hao (ORCID: https://orcid.org/0009-0002-1586-5093)
- Junyue Tao (ORCID: https://orcid.org/0000-0003-2095-5958)
- Xiaokang Bian
- C. W. Song (ORCID: https://orcid.org/0000-0002-8647-0593)
- Qintao Ge (ORCID: https://orcid.org/0000-0001-5040-6699)
- Jialing Meng
- Yiding Chen
- Jun Zhou (ORCID: https://orcid.org/0000-0003-0642-8676)
- Chaozhao Liang (ORCID: https://orcid.org/0000-0002-4551-9792)
- Tingting Cai (ORCID: https://orcid.org/0009-0005-0879-0291)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Anhui Medical University (CN)
- Fudan University Shanghai Cancer Center (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1618487
- Citations
- 2
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.87