The heterogeneity of genomic alterations, metastatic patterns and immune microenvironment in metastatic ovarian cancer originating from colorectal cancer
This study presents a better understanding the heterogeneity of the genetic characterizations and metastatic pattern in CRCOM. The subtypes of CRCOM with USP7 mutation, more copy number alterations, lower neoantigens, and immunoscore have a worse prognosis.
Authors
- Haochen Gu (ORCID: https://orcid.org/0009-0005-8811-8736)
- Yingkuan Shao (ORCID: https://orcid.org/0000-0001-9683-5691)
- Yini Li (ORCID: https://orcid.org/0009-0006-3544-8640)
- Lifeng Sun
- Binjie Sun
- Zhiwei Zhang (ORCID: https://orcid.org/0000-0003-3652-2911)
- Da Wang (ORCID: https://orcid.org/0000-0003-4955-8999)
- Jian Wang (ORCID: https://orcid.org/0000-0002-9849-7558)
- Chao Chen (ORCID: https://orcid.org/0000-0003-0990-5239)
- Yuyan Zheng (ORCID: https://orcid.org/0009-0001-4637-8127)
- Zhiyuan Gong (ORCID: https://orcid.org/0000-0002-7518-2836)
- Lijia Ma (ORCID: https://orcid.org/0000-0002-1201-8051)
- Xiaoxu Ge (ORCID: https://orcid.org/0000-0002-2533-9057)
- Yeting Hu
- Kefeng Ding
- Akao Zhu (ORCID: https://orcid.org/0000-0002-6394-5592)
Institutions
- Fudan University (CN)
- Westlake University (CN)
- Zhejiang Cancer Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1593439
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China