Hemoglobin-associated CALR in proximal tubule cells can be used as a biomarker for idiopathic membranous nephropathy
Our findings demonstrate that the <i>CALR</i> gene is significantly associated with IMN pathogenesis and progression. Functionally, <i>CALR</i> plays crucial roles in both immune response (particularly in antigen presentation) and physiological processes (notably in hemoglobin production).
Authors
- Yangen Huang (ORCID: https://orcid.org/0000-0002-2608-7728)
- Bingmei Feng (ORCID: https://orcid.org/0009-0000-4566-2532)
- Zige Liu (ORCID: https://orcid.org/0000-0002-6659-3692)
- Shuting Pang (ORCID: https://orcid.org/0009-0001-2481-4581)
- Rongbin Zhou (ORCID: https://orcid.org/0000-0002-3351-6420)
- Boyu Zhao (ORCID: https://orcid.org/0000-0002-2521-2443)
- Qi Tan (ORCID: https://orcid.org/0000-0002-3384-3544)
- Wei Li (ORCID: https://orcid.org/0000-0002-3332-1287)
- Shanshan Li (ORCID: https://orcid.org/0000-0001-6443-958X)
- Yuli Xie
- Rirong Yang (ORCID: https://orcid.org/0000-0003-1571-5925)
- Boji Xie
- Haiyuan Wei
- Mujia Jili
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Center for Genomic Science (IT)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3389/fmed.2025.1574852
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00