Risk of ovarian cancer in women with pelvic inflammatory disease and homologous recombination repair gene mutations under 55: a population-based cohort study
An association between PID and OC risk emerged, notably in the subgroup aged younger than 55 years old. Individuals with both a PID history and gHR mutations exhibited the highest risk of OC. These findings imply PID as a potential precursor for OC, underscoring the importance of early intervention, particularly in the younger population with gHR mutations.
Authors
- Fuxia Li (ORCID: https://orcid.org/0000-0002-2481-0740)
- Rourou Xiao
- Chenzhao Feng (ORCID: https://orcid.org/0000-0001-6018-7768)
- Beibei Wang (ORCID: https://orcid.org/0000-0002-7091-2772)
- Wanwan Luo (ORCID: https://orcid.org/0000-0002-6424-021X)
- Xi Cao (ORCID: https://orcid.org/0000-0003-4826-2862)
- Zanhong Wang (ORCID: https://orcid.org/0000-0002-1339-4411)
- Xiao-yuan Hao (ORCID: https://orcid.org/0000-0002-9942-9127)
- Chaoyang Sun (ORCID: https://orcid.org/0000-0003-2469-1638)
- Gang Chen (ORCID: https://orcid.org/0000-0001-8248-7219)
- Zhiqiang Han (ORCID: https://orcid.org/0000-0001-6222-9183)
- Chunlin Dong (ORCID: https://orcid.org/0000-0001-9345-392X)
- Yang Bin (ORCID: https://orcid.org/0000-0002-4508-8136)
Institutions
- Shihezi University (CN)
- Jiangnan University (CN)
- Wuhan University (CN)
- Wuxi Fourth People's Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Shanxi Academy of Medical Sciences (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Gynecologic Oncology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3802/jgo.2025.36.e126
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities