The impact and mechanisms of CRIP2 on the biological behavior of triple-negative breast cancer cells
Up-regulation of CRIP2 inhibits the proliferation, migration and invasive capacity of MDA-MB-231 cells, up-regulation of CRIP2 inhibits P65 phosphorylation, over-expression of MAP2K4 down-regulates CRIP2 expression, and up-regulation of CRIP2 reverses the ability of MAP2K4 over-expression to promote the malignant phenotype of breast cancer.
Authors
- Huahai Mao (ORCID: https://orcid.org/0000-0002-8493-9802)
- Jianwei Jiang (ORCID: https://orcid.org/0000-0002-2509-7828)
- Yu Ren (ORCID: https://orcid.org/0000-0003-2928-138X)
- Shuming Liu (ORCID: https://orcid.org/0000-0002-4949-4318)
- Hongming Chen (ORCID: https://orcid.org/0000-0003-3948-6952)
- Zhihua Tan
- Xiangning Meng
Institutions
- Guiyang Medical University (CN)
Publication Details
- Journal
- Translational Breast Cancer Research
- Published
- 2025-06-11
- DOI
- https://doi.org/10.21037/tbcr-24-57
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00