Glymphatic dysfunction is related to motor disability fully mediated by gray matter degeneration in early-stage Parkinson's disease
Glymphatic dysfunction in early-stage PD correlates with GM degeneration and motor decline. Left posterior cingulate degeneration fully mediates the impact of glymphatic dysfunction on motor disability. These findings deepen the understanding of the clinical relevance of glymphatic dysfunction and provide further insights into the regulatory mechanisms underlying PD-related neurodegenerative circuits.
Authors
- Baorong Zhang (ORCID: https://orcid.org/0000-0002-8099-7407)
- Xiaojie Duanmu
- Cheng Zhou (ORCID: https://orcid.org/0000-0002-4091-4777)
- Nan Lu (ORCID: https://orcid.org/0000-0002-3056-7871)
- Xiaojun Xu (ORCID: https://orcid.org/0009-0006-5143-2470)
- Jianmei Qin
- Lifang Wang (ORCID: https://orcid.org/0009-0002-2586-1993)
- Tao Guo (ORCID: https://orcid.org/0000-0002-7340-3762)
- Yue Jin (ORCID: https://orcid.org/0000-0001-5546-9525)
- Lu Wang (ORCID: https://orcid.org/0000-0003-2617-655X)
- Jingwen Chen (ORCID: https://orcid.org/0000-0002-5756-3336)
- Jingjing Wu (ORCID: https://orcid.org/0000-0002-6396-817X)
- Xiaojun Guan
- Chenqing Wu
- Weijin Yuan
- Jiaqi Wen (ORCID: https://orcid.org/0000-0002-4520-4395)
- Yaping Yan (ORCID: https://orcid.org/0000-0002-9309-4848)
- Qianshi Zheng
- Zihao Zhu (ORCID: https://orcid.org/0000-0003-2768-8477)
- Ziyi Zhu (ORCID: https://orcid.org/0000-0001-8890-7894)
- Yuelin Fang
- Haoting Wu
- Bingting Zhu
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.nbd.2025.107001
- Citations
- 5
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 4.55
Funders
- National Natural Science Foundation of China