Intratympanic dexamethasone microcrystal-loaded porous PLGA microspheres containing lipoic acid for combined delivery to the inner ear
This novel codelivery system combining microcrystals and porous microspheres achieves sustained dual-drug release, enhances therapeutic efficacy, and offers a promising strategy for managing hearing loss via intratympanic administration.
Authors
- Jianjun Sun (ORCID: https://orcid.org/0000-0002-6015-738X)
- Dongcheng Wang (ORCID: https://orcid.org/0000-0001-5292-9346)
- Mingfang Diao (ORCID: https://orcid.org/0000-0003-1912-5500)
- Zhimin Zhou (ORCID: https://orcid.org/0000-0003-4832-3530)
- Peili Zhang (ORCID: https://orcid.org/0000-0001-9171-935X)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-5113-1420)
- Jingjie Wang
- Zongyi Wu (ORCID: https://orcid.org/0000-0002-7227-1825)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Wenzhou Medical University (CN)
- Chinese PLA General Hospital (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Peking University International Hospital (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Journal of Otology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.26599/joto.2025.9540029
- Citations
- 1
- Primary Topic
- Infant Health and Development
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- Natural Science Foundation of Tianjin City