An ASTCT, CIBMTR, EBMT, and APBMT Consensus Statement Defining Response Criteria for Hematopoietic Cell Transplantation Associated Thrombotic Microangiopathy (TA-TMA) Directed Therapy
The consensus response criteria proposed by this expert panel are a step towards standardizing the assessment of treatment responses of TA-TMA directed agents for future studies and interventional clinical trials. Adoption of these criteria will enhance consistency of response assessment and facilitate the comparison of TA-TMA treatments. Since achieving an early overall CR may be challenging/protracted in patients with organ injury; establishment of criteria for clinically meaningful PR is important and may be a more useful early endpoint in studies. Given the complexity of these patients and assessment of response, these definitions may need be revised in the future after application in large cohorts diverse in age, HCT approaches, and interventional agents.
Authors
- Nicolaus Martin Kröger (ORCID: https://orcid.org/0000-0001-5103-9966)
- Ivan Moiseev (ORCID: https://orcid.org/0000-0002-4332-0114)
- Sonata Jodele (ORCID: https://orcid.org/0000-0002-1791-7718)
- Per Ljungman
- Eleni Gavriilaki (ORCID: https://orcid.org/0000-0002-8883-8208)
- Enric Carreras (ORCID: https://orcid.org/0000-0002-3134-9964)
- Isabel Sánchez‐Ortega (ORCID: https://orcid.org/0009-0005-5519-9154)
- Bronwen E. Shaw (ORCID: https://orcid.org/0000-0003-3317-1896)
- Paul A Carpenter
- Alok Srivastava
- Michelle Long Schoettler (ORCID: https://orcid.org/0000-0003-4565-6399)
- Vincent T. Ho
- Christopher E. Dandoy (ORCID: https://orcid.org/0000-0002-4001-9203)
- Uday Popat (ORCID: https://orcid.org/0000-0002-7592-2224)
- Robert J. Soiffer (ORCID: https://orcid.org/0000-0002-5810-1192)
- John Koreth
- Sumithira Vasu (ORCID: https://orcid.org/0000-0002-8635-3880)
- Ana Maria Sureda
- Kristen Page (ORCID: https://orcid.org/0009-0001-7642-2264)
- Yoshiko Atsuta
- Cho Bo-Kyoung
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Karolinska University Hospital (SE)
- The University of Texas MD Anderson Cancer Center (US)
- Emory University (US)
- Christian Medical College, Vellore (IN)
- Medical College of Wisconsin (US)
- First Pavlov State Medical University of St. Petersburg (RU)
- Fred Hutch Cancer Center (US)
- European Molecular Biology Laboratory (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Institut Català d'Oncologia (ES)
- Aflac (United States) (US)
- Dana-Farber Cancer Institute (US)
- The Korean Society of Blood and Marrow Transplantation (KR)
- Children's Healthcare of Atlanta (US)
- The Japanese Data Center for Hematopoietic Cell Transplantation (JP)
- G. Papanikolaou General Hospital (GR)
- The Ohio State University (US)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Transplantation and Cellular Therapy
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.jtct.2025.05.028
- Citations
- 4
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- American Society of Hematology
- Robert W. Woodruff Foundation