Suppression effect of folate on poly- and perfluoroalkyl substance-induced alterations in lipids and the atherogenic index of plasma in adolescents
PFAS exposure may be associated with dyslipidemia and impaired cardiovascular health in adolescents, while folate could potentially attenuate the direct association between PFAS exposure and these health outcomes. In the future, maintaining normal levels of folate in the body could be a key strategy in preventing disruptions to lipid metabolism and potential threats to cardiovascular health in adolescents caused by PFAS.
Authors
- Krishna Baral
- Mingyi Zhao (ORCID: https://orcid.org/0000-0002-2884-0736)
- Yuyang Ma
- Chen Cheng (ORCID: https://orcid.org/0000-0003-2538-9123)
- Mengchang Xu (ORCID: https://orcid.org/0000-0002-2590-9814)
- Shaoyu He
- Linyong Xu (ORCID: https://orcid.org/0000-0001-5130-2461)
- Yuxin Pan (ORCID: https://orcid.org/0009-0007-3585-8807)
- Ziye Du
- Manling Zhang (ORCID: https://orcid.org/0000-0002-5447-2615)
Institutions
- Central South University (CN)
- Changsha Medical University (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s12944-025-02638-y
- Citations
- 4
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- Central South University
- Xiangya Hospital, Central South University