Janus Kinase Inhibitor-Induced Acne in Inflammatory Bowel Disease: An International, Multicenter, Retrospective Cohort Study
This is the first study characterizing this adverse event in JAK inhibitor-treated patients with IBD and presents the largest cohort of JAK inhibitor-induced acne cases across all immune-mediated diseases. Acne is a common adverse effect resulting in significant psychological burden. Early identification, proactive counseling, and timely interventions, such as dose reduction or referral to dermatology, are crucial in managing this side effect.
Authors
- Samantha Baillie (ORCID: https://orcid.org/0000-0003-3280-0347)
- Naomi N. Shields
- Stéphane Nancey (ORCID: https://orcid.org/0000-0003-2088-1442)
- Ellen Thompson (ORCID: https://orcid.org/0000-0002-4029-5398)
- Fakhirah Badrulhisham
- Sailish Honap (ORCID: https://orcid.org/0000-0001-6657-2763)
- Milan Lukáš (ORCID: https://orcid.org/0000-0002-1463-3840)
- João João Mendes (ORCID: https://orcid.org/0000-0003-0277-3309)
- Sonia Mehta (ORCID: https://orcid.org/0009-0007-8228-376X)
- Shahida Din (ORCID: https://orcid.org/0000-0003-2855-3400)
- Ferdinando D’Amico (ORCID: https://orcid.org/0000-0002-8591-6995)
- William J. McBride (ORCID: https://orcid.org/0000-0001-8894-533X)
- Catarina O’Neill (ORCID: https://orcid.org/0000-0002-5412-1022)
- Sophie Vieujean (ORCID: https://orcid.org/0000-0002-1859-7146)
- Ailsa L Hart (ORCID: https://orcid.org/0000-0002-7141-6076)
- Maria Manuela Estevinho
- Anish John Kuriakose Kuzhiyanjal (ORCID: https://orcid.org/0000-0002-5161-1747)
- Shaji Sebastian (ORCID: https://orcid.org/0000-0002-3670-6545)
- Ashley Spencer (ORCID: https://orcid.org/0000-0003-3386-8458)
- Gareth Parkes (ORCID: https://orcid.org/0000-0002-5285-7714)
- Fernando Magro (ORCID: https://orcid.org/0000-0003-2634-9668)
- Jonathan Digby‐Bell (ORCID: https://orcid.org/0000-0002-1378-1219)
- Eathar Shakweh
- Ningyu Chai
- Polychronis Pavlidis (ORCID: https://orcid.org/0000-0003-4864-2208)
- B. Wegener
- Inês Simão (ORCID: https://orcid.org/0000-0003-4872-7455)
- María José Temido (ORCID: https://orcid.org/0000-0002-0283-8507)
- Akira Nogami (ORCID: https://orcid.org/0009-0003-0706-0436)
- Jimmy K. Limdi (ORCID: https://orcid.org/0000-0002-1039-6251)
- Joana Camões Neves (ORCID: https://orcid.org/0000-0001-5977-835X)
- Emilie Bergereau
- Mathieu Uzzan
- Laurent Peyrin-Biroulet
- Mathurin Fumery (ORCID: https://orcid.org/0000-0002-2337-2902)
- Taku Kobayashi
- Rita de Cássia Leite Fernandes (ORCID: https://orcid.org/0009-0008-9113-6777)
- Amina Jama
- Madalina Gututui
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Imperial College Healthcare NHS Trust (GB)
- Vita-Salute San Raffaele University (IT)
- Inserm (FR)
- Universidade do Porto (PT)
- King's College London (GB)
- Örebro University (SE)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- London North West Healthcare NHS Trust (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Royal London Hospital (GB)
- Hospitais da Universidade de Coimbra (PT)
- Edinburgh Cancer Research (GB)
- Hospital de São João (PT)
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Northern Health and Social Care Trust (GB)
- Manchester University NHS Foundation Trust (GB)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Hospices Civils de Lyon (FR)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- King's College Hospital NHS Foundation Trust (GB)
- Iscare I.V.F (CZ)
- Centro Hospitalar de Lisboa Ocidental (PT)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Centre Hospitalier Universitaire de Liège (BE)
- Centre for Health Technology and Services Research (PT)
- Hospital Braga (PT)
- Centro Hospitalar de Vila Nova de Gaia (PT)
- Hospital de Santa Maria (PT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Kitasato Institute Hospital (JP)
- Centro Hospitalar do Porto (PT)
- Royal London Hospital for Integrated Medicine (GB)
- Périnatalité & Risques Toxiques (FR)
- Unidade Hospitalar de Bragança (PT)
- Nutrition-Génétique et Exposition aux Risques Environnementaux (FR)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Université de Picardie Jules Verne (FR)
- Imperial College London (GB)
- Kitasato University (JP)
- Université de Lorraine (FR)
Publication Details
- Journal
- Clinical Gastroenterology and Hepatology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.cgh.2025.04.031
- Citations
- 13
- Primary Topic
- Acne and Rosacea Treatments and Effects
- Type
- article
- Field-Weighted Citation Impact
- 26.06