Expression of piR-34377 in Endometrial Adenocarcinoma and Its Clinicopathological Significance

目的：探讨piR-34377在子宫内膜腺癌及癌旁正常组织中的表达、临床病理意义和预后价值。方法：通过piRNA表达谱芯片筛选出子宫内膜腺癌及癌旁正常组织差异表达的piR-34377；选择69例子宫内膜腺癌通过qRT-PCR实验进行验证；分析piR-34377表达与子宫内膜腺癌患者临床病理特征和预后之间的关联。结果：piRNA表达谱测序结果得到包含piR-34377在内的2个piRNA表达水平下降。qRT-PCR实验验证结果表明，piR-34377 (1.962 ± 0.1152)表达水平明显低于癌旁正常组织(4.337 ± 0.2228)，t = 8.976，P P P Objective: To investigate the expression, clinicopathological significance and prognostic value of piR-34377 in endometrial adenocarcinoma and adjacent normal tissues. Methods: piR-34377 differentially expressed in endometrial adenocarcinoma and adjacent normal tissues was screened by piRNA expression profile chip. Sixty-nine cases of endometrial adenocarcinoma were selected and verified by qRT-PCR. The correlation between piR-34377 expression and clinicopathological features and prognosis of patients with endometrial adenocarcinoma was analyzed. Results: The results of piRNA expression profile sequencing showed that the expression level of 2 piRNAs, including piR-34377, was decreased. qRT-PCR results showed that the expression level of piR-34377 (1.962 ± 0.1152) was significantly lower than that of adjacent normal tissues (4.337 ± 0.2228), t = 8.976, P P P < 0.05). Conclusions: The expression of piR-34377 is down-regulated in endometrial adenocarcinoma tissues. piR-34377 expression is closely related to lymph node metastasis, stage and poor prognosis.