Finite Element Model of Biological Tissue Damage under Hypothermia-Mechanical Coupling Effect

冷冻消融术作为目前治疗肿瘤的重要方法之一，具有安全、高效、微创等优势。然而，脑肿瘤冷冻消融术中引发的颅内压波动现象未得到足够的重视。研究颅内温度与压力相互作用的机制，或许有助于解决这一问题。文章考虑温度和围压的耦合作用，构建了肿瘤冻结后机械损伤的有限元模型，评估低温环境下生物组织冻结后力学性能的影响及损伤规律。并采用COMSOL数值模拟胶质瘤低温消融中颅内温度–力学耦合的响应机制。Cryoablation, as one of the important methods for the treatment of tumors, has advantages such as safety, efficiency, and minimal invasiveness. However, the phenomenon of intracranial pressure fluctuation caused by brain tumor cryoablation has not received enough attention. Studying the mechanism of the interaction between intracranial temperature and pressure may help to solve this problem. Considering the coupling effect of temperature and confining pressure, a finite element model of tumor mechanical damage after freezing was constructed to evaluate the effect of freezing on mechanical properties and the damage law of biological tissues in a low-temperature environment. COMSOL was used to simulate the response mechanism of intracranial temperature-mechanical coupling during glioma cryoablation.