Dysregulated lipid metabolism in late preterm low birth weight neonates: A case-control study on maternal lipid levels and early metabolic programming implications
LPTB-LBW neonates exhibit a unique lipidomic phenotype marked by hyperaccumulation of glycerolipids (<i>e.g.</i>, long-chain polyunsaturated TGs), elevated ceramides, and altered phospholipid species (increased PE, decreased PG). Maternal HDLC levels negatively correlated with specific neonatal lipids. These findings highlight early-life lipid alterations in LPTB-LBW infants and the need for further investigation into their clinical implications.
Authors
- Di Lv
- Lijuan Tang
- Yuanmei Chen (ORCID: https://orcid.org/0000-0002-3804-731X)
- Qi Zhang (ORCID: https://orcid.org/0000-0001-5803-2556)
- Jing Liu (ORCID: https://orcid.org/0000-0001-6520-9612)
- Chao Wang (ORCID: https://orcid.org/0000-0003-2737-4048)
- Qi Sun (ORCID: https://orcid.org/0000-0001-5182-4278)
- Haixiao Liang
- Fang Ye (ORCID: https://orcid.org/0000-0001-8507-0734)
- Hui Qin (ORCID: https://orcid.org/0000-0002-2242-8257)
- Die Liu (ORCID: https://orcid.org/0009-0005-0169-5769)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-06-11
- DOI
- https://doi.org/10.7717/peerj.19542
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00