Effect of titanium nanoparticles on cytotoxicity and expression of matrix metalloproteinase-8 in human periodontal ligament fibroblasts – An in vitro study

Within the study's limitations, the cytotoxic and immunological responses of HPDLFs to titanium (Ti) are directly linked to the concentration and duration of exposure. Although no significant differences in MMP-8 release were observed across varying TiO2 concentrations, a decrease in cell viability was associated with higher TiO2 levels.