Electrochemical Cross-Dehydrogenative Coupling of P(O)–H/P–H Bonds with Heteroatom Nucleophiles: Access to P(O)–N and P(S)–X Compounds
A unified electrochemical cross-dehydrogenative coupling (CDC) of heteroatom nucleophiles with H-phosphine oxides, H-phosphinates, H-phosphites, and in situ-formed H-phosphine sulfides has been developed for the synthesis of <i>N</i>-aryl phosphamides, phosphoramidates, thiophosphamides, phosphinodithioates, and phosphinothioates. This electrochemical reaction exhibited good function tolerance and high atomic economy under metal-, light-, base-, and oxidant-free conditions with releasing molecular hydrogen as the sole and nontoxic byproduct.
Authors
- Sifeng Li (ORCID: https://orcid.org/0000-0002-5302-1599)
- Dilnigar Askar
- Ablikim Obolda (ORCID: https://orcid.org/0000-0001-8614-6438)
- Jigang Gao (ORCID: https://orcid.org/0009-0009-8967-7993)
- Bin Cheng (ORCID: https://orcid.org/0000-0002-8276-6653)
- Xiao Li (ORCID: https://orcid.org/0000-0002-0356-2426)
- Xingchen Li
- Xiaoye Mo (ORCID: https://orcid.org/0000-0001-9828-4635)
Institutions
- University of Science and Technology Liaoning (CN)
- Xinjiang Agricultural University (CN)
- Shenzhen Polytechnic University (CN)
- The Polytechnic University of Japan (JP)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1021/acs.joc.5c00760
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- Department of Education of Guangdong Province
- Science, Technology and Innovation Commission of Shenzhen Municipality