Exogenous Ubiquitin Differentially Modulates the Phenotype and Function of M1 and M2 Macrophages
eUB modulates macrophage polarization, reduces pro-inflammatory cytokine secretion, and alters functional parameters and intracellular signaling. These effects may contribute to the cardioprotective potential of eUB 3 days post-I/R injury.
Authors
- Hui Wang‐Heaton
- Mahipal Singh (ORCID: https://orcid.org/0000-0002-1369-9370)
- Paige L. Shook
- Suman Dalal (ORCID: https://orcid.org/0000-0003-4119-6209)
- Valentin P. Yakubenko (ORCID: https://orcid.org/0000-0002-0242-3061)
- Krishna Singh (ORCID: https://orcid.org/0000-0003-0399-2191)
- Jared L. Casteel (ORCID: https://orcid.org/0000-0001-7737-4711)
Institutions
- East Tennessee State University (US)
- James H. Quillen VA Medical Center (US)
Publication Details
- Journal
- Cells
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3390/cells14120879
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Office of Research and Development
- National Institutes of Health
- National Heart, Lung, and Blood Institute