Human saliva exerts strong type-dependent effects on adenovirus infectivity
Saliva may have a protective role against infection by certain types of Ads. This discovery highlights a potential limitation in the efficacy of next-generation oral Ad vaccine vectors. Consequently, our study underscores the importance of identifying and utilizing saliva-resistant Ad vectors to optimize Ad-based vaccination strategies.
Authors
- Anja Ehrhardt (ORCID: https://orcid.org/0000-0002-6639-4888)
- Inga Marte Charlott Seuthe (ORCID: https://orcid.org/0000-0002-0295-5447)
- Erwan Sallard (ORCID: https://orcid.org/0000-0002-2324-3633)
- Wenli Zhang (ORCID: https://orcid.org/0000-0002-6243-6286)
- Malik Aydin (ORCID: https://orcid.org/0000-0002-1340-9687)
- Nikita Chilakamarri
- Setareh Farzanehkari
Institutions
- Witten/Herdecke University (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1579896
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Oxford
- Deutsche Forschungsgemeinschaft