Daidzein-rich isoflavone aglycones inhibit 17β-hydroxysteroid dehydrogenase 1 and increase estrogen sulfotransferase in endometriosis
DRIA treatment could suppress abnormal estrogen production via EST stimulation as well as the inhibition of aromatase and HSD17β1 activities, suggesting therapeutic potential in endometriosis that needs to be confirmed by our ongoing clinical trial. ay.
Authors
- Koki Shimura (ORCID: https://orcid.org/0000-0001-7834-985X)
- Hiroyuki Okimura (ORCID: https://orcid.org/0000-0002-2154-1602)
- Jo Kitawaki (ORCID: https://orcid.org/0000-0002-4359-959X)
- Yuko Izumi (ORCID: https://orcid.org/0000-0003-1189-7987)
- Akihisa Katayama
- Yosuke Tarumi (ORCID: https://orcid.org/0000-0002-6058-594X)
- Taisuke Mori (ORCID: https://orcid.org/0000-0002-9792-4132)
- Fumitake Ito (ORCID: https://orcid.org/0000-0001-6847-0779)
- Osamu Takaoka
- Izumi Kusuki (ORCID: https://orcid.org/0000-0001-5563-9707)
- Hisashi Kataoka
Institutions
- Kyoto Prefectural University of Medicine (JP)
Publication Details
- Journal
- Gynecological Endocrinology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1080/09513590.2025.2516202
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology