A Comprehensive Analysis of Therapeutic Plants and Substances to Enhance Pancreatic β-Cell Mass and Functionality in the Treatment of Diabetic Mellitu

Diabetes represents a significant financial burden at a national level and poses a global health concern. Despite the presence of numerous antidiabetic drugs in the market, there remains a demand for novel treatment options that offer enhanced effectiveness and reduced side effects. The appeal of medications derived from natural compounds surpasses that of their synthetic counterparts due to their diverse nature and minimal occurrence of adverse reactions. This review encompasses the primary effects of various naturally occurring substances obtained from plants on the functionality of pancreatic beta cells. Studies have indicated that these natural substances have the ability to alter the growth and division of pancreatic beta cells, prevent their demise, and directly enhance the production of insulin. Investigating natural compounds as potential sources for advanced medications is of utmost importance. Consequently, further exploration into the mode of action of these compounds is imperative to advance their potential as prospective anti-diabetic agents.