GMPS inhibits the proliferation and migration of non-small cell lung cancer via the regulation of the DNMT 1/SERPINB2 axis
Our findings revealed the correlation between GMPS and the prognosis of NSCLC at the tissue level. Secondly, GMPS can promote the progression of NSCLC. The molecular mechanism of GMPS affecting the metastasis of lung cancer cells was elucidated. These findings highlight the important role of GMPS in NSCLC, so as to provide new insights for the identification of new targets and lay a theoretical foundation for the clinical application of GMPS.
Authors
- Lingyan Zeng (ORCID: https://orcid.org/0000-0002-4583-002X)
- Tingting Guo (ORCID: https://orcid.org/0000-0002-9440-3243)
- Ying Yang (ORCID: https://orcid.org/0000-0002-4810-2976)
- Lei Liu (ORCID: https://orcid.org/0000-0002-0500-6239)
- Huachang Zhao
- Tingting Song (ORCID: https://orcid.org/0000-0002-2305-2300)
- Zhixin Qiu (ORCID: https://orcid.org/0000-0003-0256-4419)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1007/s13402-025-01078-1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China