Prediabetes Subgroups, Type 2 Diabetes Risk, and Differential Effects of Preventive Interventions
Pathophysiologically distinct prediabetes subgroups differ in risk for diabetes and preventive benefit from metformin. These results support distinct mechanisms of diabetes susceptibility; however, the use of clinical prediction models to guide treatment decisions may provide adequate risk profiling.
Authors
- Brian J. Wells (ORCID: https://orcid.org/0000-0001-7310-6525)
- Ramon Casanova (ORCID: https://orcid.org/0000-0002-6934-5942)
- Byron C. Jaeger (ORCID: https://orcid.org/0000-0001-7399-2299)
- Jeanette M. Stafford (ORCID: https://orcid.org/0000-0001-6307-1517)
- Michael P. Bancks (ORCID: https://orcid.org/0000-0003-3694-6060)
- Yitbarek N Demesie
Institutions
- Wake Forest University (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1210/clinem/dgaf350
- Citations
- 3
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- U.S. Department of Health and Human Services
- American Diabetes Association
- Bristol-Myers Squibb
- Deutsches Krebsforschungszentrum
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Institute on Aging
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development
- Office of Research on Women's Health