Exosomal ITGB2 Mediates Immune Evasion in Triple-Negative Breast Cancer by Suppressing Dendritic Cell Activation via TLR4
Targeting the <i>ITGB2</i>-<i>TLR4</i> axis could enhance anti-tumor immunity in TNBC. <i>ITGB2</i> holds potential as a biomarker and therapeutic target, suggesting that inhibition of exosomal <i>ITGB2</i> or restoration of DC function may improve therapeutic outcomes in TNBC.
Authors
- Puerkaiti Paierhati
- Muzhapaer Abudukeremu (ORCID: https://orcid.org/0009-0008-6163-4492)
- Binlin Ma (ORCID: https://orcid.org/0000-0002-1272-7261)
Institutions
- Xinjiang Medical University (CN)
- Tumor Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Iranian Journal of Public Health
- Published
- 2025-06-11
- DOI
- https://doi.org/10.18502/ijph.v54i6.18903
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00