Canine leishmaniosis and peripheral neuropathy: a lesson from the neurologist
Peripheral neuropathies during active CanL can be a consequence of sCIC deposition on endoneurial vascular endothelium comprising the blood-nerve barrier and its consequent breakdown. However, an abnormal host immune response triggered by L. infantum causing demyelination and/or axonal disruption is also possible. The positive response to the immunosuppressive therapy further supports an immune-mediated origin of the PNS condition. Therefore, CanL should be included in the differential diagnosis of PNS disease in dogs, especially in areas endemic for L. infantum.
Authors
- Andrea Zatelli (ORCID: https://orcid.org/0000-0003-0001-7710)
- Kaspar Matiasek (ORCID: https://orcid.org/0000-0001-5021-3280)
- Floriana Gernone (ORCID: https://orcid.org/0000-0002-6256-3832)
- Annamaria Uva (ORCID: https://orcid.org/0009-0006-4375-906X)
- Jairo Alfonso Mendoza‐Roldan (ORCID: https://orcid.org/0000-0001-9787-932X)
Institutions
- City University of Hong Kong (HK)
- Hong Kong Jockey Club (HK)
- University of Bari Aldo Moro (IT)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s13071-025-06773-4
- Citations
- 2
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Elanco Animal Health