Investigation of serum vitamin D levels in mothers of infants with congenital heart diseases in Urmia city in 2023

Background & Aims: Vitamin D can play a vital role in fetal heart development.This study investigated serum vitamin D levels in mothers of infants with congenital heart diseases.Materials & Methods: This study was a case-control study in which 50 mothers of infants with congenital heart defects (case group) and 50 mothers of healthy infants (control group) were examined.The required information for the study included maternal age, vitamin D supplementation, duration of supplementation, family history of congenital heart disease, and serum vitamin D levels.The collected information was then analyzed.. Results:The mean serum vitamin D level in the case group was higher than the control group, but there was no statistically significant difference (P = 0.182).There was no significant relationship between the severity of vitamin D deficiency and the presence of congenital heart disease.(P = 0.695).The mean serum vitamin D level in the cyanotic group was higher than the asiatic group, but there was no significant difference according to the independent t-test (P = 0.42).Also, there was no significant relationship between the severity of vitamin D deficiency in the mother and cyanotic or asiatic status of the newborn (P = 0.102).The duration of vitamin D supplementation in the case group was slightly longer than in the control group and was significantly associated with the presence of heart defects in the newborn (P = 0.026).In the case group, there were more people with a history of congenital heart disease in their first-degree relatives than in the control group and was significantly associated with the presence of congenital heart disease in the newborn (P < 0.001). Conclusion:In this study, significant relationship was found between vitamin D supplementation and its blood level in the mother with congenital heart disease in the newborn.However, since vitamin D deficiency in the body can cause serious complications in the individual, it is recommended that pregnant women, especially in the first trimester of pregnancy, consume sufficient vitamin D supplements.