Causal relationships between alterations in shear stress-related genes and aneurysmal subarachnoid hemorrhage
Our findings suggest a causal relationship between alterations in SS-related genes and aSAH. Specifically, KCNN4 and UGCG emerge as potential biomarkers critical in the disease progression of aSAH. These insights contribute to a better understanding of the molecular basis of aSAH and may guide future therapeutic strategies targeting SS-related pathways.
Authors
- Yi Xie (ORCID: https://orcid.org/0000-0001-8095-4856)
- Xiaoxin Wu (ORCID: https://orcid.org/0000-0001-9785-8916)
- Wenli Sheng (ORCID: https://orcid.org/0000-0001-6867-371X)
- Jiaoxing Li (ORCID: https://orcid.org/0000-0001-6351-8833)
- Xingyang Niu
- Fei Ye (ORCID: https://orcid.org/0000-0002-2359-1486)
- Minghao Zhang (ORCID: https://orcid.org/0000-0002-1693-2633)
- Yuanyuan Dai (ORCID: https://orcid.org/0000-0001-6487-7803)
Institutions
- Army Medical University (CN)
- Sun Yat-sen University (CN)
- National University of Singapore (SG)
- Duke-NUS Medical School (SG)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Southwest Hospital (CN)
- National Neuroscience Institute (SG)
- Woodlands Health Campus (SG)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s13023-025-03784-3
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment