Aquaporin‐4‐Mediated Water Permeability Rescues Aquaporin‐3 Deficiency Caused Nephrogenic Diabetes Insipidus
In situ replacement of AQP3 with AQP4 restores AQP3-mediated water permeability in the renal collecting duct, rescuing the nephrogenic diabetes insipidus (NDI) phenotype in AQP3-deficient mice. This study provides evidence that AQP3-mediated water permeability plays a crucial role in the renal urine concentrating mechanism.
Authors
- Jihan Liu
- Yazhu Quan
- Zhiwei Qiu (ORCID: https://orcid.org/0000-0003-4085-4302)
- Baoxue Yang (ORCID: https://orcid.org/0000-0002-7966-2095)
- Yongpan An
- Keying Wang (ORCID: https://orcid.org/0000-0001-6950-0087)
- Feng Lu (ORCID: https://orcid.org/0000-0003-3933-8490)
- Ying Yi (ORCID: https://orcid.org/0000-0003-1434-1458)
- Hong Zhou (ORCID: https://orcid.org/0000-0002-3809-3949)
- Min Li (ORCID: https://orcid.org/0009-0001-3963-0478)
Institutions
- Peking University (CN)
- Peking University First Hospital (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1111/apha.70072
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China