Shampoo Containing ScalpCleanse? vs Marketed Shampoo in Dandruff Management: A Randomized, Double-Blind, Comparative Study

This randomized, double-blind clinical trial compares the safety and efficacy of an anti-dandruff shampoo containing ScalpCleanse?, a proprietary combination of phytochemicals, to a standard ketoconazole-zinc pyrithione shampoo. Forty participants with mild to moderate dandruff used one of the two shampoos over 30 days. Clinical parameters of dandruff severity, scaling (adherent and non-adherent), erythema, scalp sebum levels, itching, and dryness were evaluated at multiple time points, along with participant self-assessment and safety and tolerability. Results revealed significant improvements in both groups, including significant and comparable reductions in adherent and non adherent dandruff by the end of the study. Both shampoos also significantly reduced erythema, itching, dryness and sebum production. Shampoo containing ScalpCleanse? showed a numerically greater reduction in erythema and dryness. Both products were well-tolerated with no serious adverse events reported. The study concluded that shampoo containing ScalpCleanse? is equally effective and safe as the marketed ketoconazole and zinc pyrithone shampoo in the treatment of dandruff and associated symptoms. An anti-dandruff shampoo containing ScalpCleanse? presents a viable alternative to synthetic antifungal shampoos.