C <sub>19</sub> -Diterpenoid alkaloids from two plants of <i>Aconitum sinoaxillare</i> and <i>Aconitum chasmanthum</i>
Five new compounds (<b>1</b>-<b>5</b>) were isolated from the whole plants of two species of <i>Aconitum</i>, including two aconitine-type C<sub>19</sub>-diterpenoid alkaloids, sinoaxidines A (<b>1</b>) and B (<b>2</b>) and a franchetine-type C<sub>19</sub>-diterpenoid alkaloid, sinoaxidine C (<b>3</b>) from <i>Aconitum sinoaxillare</i> W. T. Wang. Two aconitine-type C<sub>19</sub>-diterpenoid alkaloids, chasmanthumines A (<b>4</b>) and B (<b>5</b>) from <i>Aconitum chasmanthum</i> Stapf, and forty known diterpenoid alkaloids were also isolated. The structures of all compounds were identified based on extensive IR, 1D, 2D NMR and HR-ESI-MS data analysis. Compound <b>6</b> exhibited potent inhibitory effects on the production of NO in RAW 264.7 cells with IC<sub>50</sub> of 29.60 <i>μ</i>M respectively.
Authors
- Mei–Zhen Ye
- Lin Chen (ORCID: https://orcid.org/0000-0002-4160-8077)
- Tingting Li (ORCID: https://orcid.org/0000-0002-6338-2769)
- Long Qian (ORCID: https://orcid.org/0000-0003-4795-5114)
- Xian‐Li Zhou (ORCID: https://orcid.org/0000-0002-1690-0578)
- Shu Wang (ORCID: https://orcid.org/0000-0001-8781-2535)
- Min Zhang (ORCID: https://orcid.org/0000-0002-0905-9303)
- Ling-Feng Tian
- Shuai Huang
Institutions
- Yibin University (CN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1080/10286020.2025.2513492
- Primary Topic
- Plant-based Medicinal Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China