A Rare Case of Juvenile Myelomonocytic Leukemia (JMML) with t(3;5)(q25;q34)/NPM::MLF1 Fusion Gene in a Pediatric Patient

This case represents a rare presentation of JMML with t(3;5)(q25;q34) involving the NPM::MLF1 fusion gene, a finding uncommon in pediatric myeloid malignancies. The presence of this genetic abnormality presents significant diagnostic and therapeutic challenges, emphasizing the need for comprehensive genetic profiling in JMML. The rarity of the NPM::MLF1 fusion complicates the establishment of a standard treatment proto-col, underscoring the necessity for individualized treatment approaches and further research.