Increased immune activation in people living with HIV on antiretroviral therapy but not when compared with persons on HIV preexposure prophylaxis
Increased levels of immune activation and neuronal injury markers were found in virologically suppressed MSM with HIV and MSM on PrEP compared with controls. These findings imply that other factors than HIV contribute to the residual immune activation and impact on neurons observed in MSM with HIV on ART, and emphasize the importance of appropriate controls with similar lifestyle in studies of biomarkers in PWH.
Authors
- Staffan Nilsson (ORCID: https://orcid.org/0000-0003-4748-0446)
- Carl-Johan Treutiger
- Johanna M. Gostner (ORCID: https://orcid.org/0000-0003-1532-5177)
- Magnus Gisslén (ORCID: https://orcid.org/0000-0002-2357-1020)
- Josefina Robertson (ORCID: https://orcid.org/0000-0002-2167-6822)
- Arvid Edén (ORCID: https://orcid.org/0000-0003-2817-9981)
- Lars Hagberg (ORCID: https://orcid.org/0000-0002-4639-2324)
- Kristina Nystrôm (ORCID: https://orcid.org/0000-0002-1692-8677)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Aylin Yilmaz (ORCID: https://orcid.org/0000-0001-7612-5828)
- Petra Tunbäck (ORCID: https://orcid.org/0000-0001-8423-8566)
- Lars-Magnus Andersson
Institutions
- Public Health Agency of Sweden (SE)
- University of Wisconsin–Madison (US)
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Sahlgrenska University Hospital (SE)
- Region Västra Götaland (SE)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Infectious Diseases
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1080/23744235.2025.2515157
- Citations
- 1
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Svenska Forskningsrådet Formas