Lamin A/C promotes HBV transcription by modulating histone modification associated with cccDNA minichromosome in an HBx-dependent manner
Our findings reveal that Lamin A/C acts as a new host factor for HBV cccDNA through an epigenetic regulatory mechanism that can interact with HBx and prevent its degradation.
Authors
- Liping Yang (ORCID: https://orcid.org/0009-0004-1574-6670)
- Linshan Jiang
- Fangli Liao
- Gaoli Zhang
- Yuanyuan Ye (ORCID: https://orcid.org/0000-0001-5848-6603)
- Hong Chen (ORCID: https://orcid.org/0000-0003-0921-2547)
- Qin Hu (ORCID: https://orcid.org/0009-0004-5466-5865)
- Weixian Chen (ORCID: https://orcid.org/0000-0001-6973-9338)
- Lanlang Peng
- Hua Sun
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s12985-025-02820-9
- Citations
- 1
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- China Postdoctoral Science Foundation
- Chongqing Science and Technology Commission
- Chongqing Medical University
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment