Effect of Cumulative Exposure to Ocrelizumab on Memory B‐Cell Repopulation Dynamics in Multiple Sclerosis
Memory B-cell repopulation becomes slower with increasing cumulative OCR dose. Age- and sex-related mechanisms probably influence repopulation dynamics. Given the evidence for a pathogenic role of memory B cells, these observations could be considered when planning extended interval dosing strategies of OCR treatment. ANN NEUROL 2025;98:603-615.
Authors
- Rosaria Sacco (ORCID: https://orcid.org/0000-0002-6623-4649)
- Giulia Mallucci (ORCID: https://orcid.org/0000-0002-0031-9594)
- Claudio Gobbi (ORCID: https://orcid.org/0000-0002-7554-0664)
- Giulio Disanto (ORCID: https://orcid.org/0000-0002-8512-6096)
- Chiara Zecca (ORCID: https://orcid.org/0000-0002-9990-3431)
Institutions
- Ospedale regionale di Lugano (CH)
- Ente Ospedaliero Cantonale (CH)
- Università della Svizzera italiana (CH)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1002/ana.27281
- Citations
- 3
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41