Single-cell transcriptome reveals the reprogramming of immune microenvironment during the transition from MASH to HCC
We illustrate the profound reprogramming of the liver immune microenvironment in the MASH-to-HCC transition and clarify the role of ApoE in MASH-driven HCC, implying that ApoE may serve as a potential therapeutic target for MASH-related HCC.
Authors
- Weihua Jiang (ORCID: https://orcid.org/0000-0002-0918-7946)
- Jin Tang (ORCID: https://orcid.org/0000-0001-9065-4021)
- Yingying Ye (ORCID: https://orcid.org/0000-0003-0056-030X)
- Yuqing Zhang (ORCID: https://orcid.org/0000-0003-0740-5310)
- Zhinan Yin (ORCID: https://orcid.org/0000-0001-6524-8777)
- Xue-Jia Lin (ORCID: https://orcid.org/0000-0002-4716-223X)
- Zhenhua Li (ORCID: https://orcid.org/0000-0001-9751-0864)
- Ying Xie (ORCID: https://orcid.org/0000-0002-0237-3244)
- Zhiying Liu (ORCID: https://orcid.org/0000-0002-2060-1597)
- Yu Huang
Institutions
- Jinan University (CN)
- Guangdong Pharmaceutical University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s12943-025-02370-2
- Citations
- 11
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 8.77
Funders
- National Natural Science Foundation of China
- Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program
- Higher Education Discipline Innovation Project
- National Key Research and Development Program of China