Solid Pseudopapillary Neoplasm of the Pancreas: Clinicopathologic Features, Review of the Literature

zObjective: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rarely seen epithelial tumor with low malignant potential.The aim of our study was to describe the morphology, differential diagnosis and prognosis of pancreatic SPNs and to present a detailed review of the literature. Methods:A retrospective analysis of all patients diagnosed and treated with SPN in our hospital between 2011 and 2021 was performed.A database of these patients including age, gender, tumor location and size, histopathological and immunohistochemical features and treatment modalities was developed. Results:The study population consisted of 8 (80%) female and 2 (20%) male patients with an overall mean age of 45.7 years (range: 10 -85 years).A 10-yearold boy was also diagnosed with neuromuscular disease.Tumor diameters ranged from 10 to 95 mm (mean: 48.5 mm).The tumor was localized in the tail of the pancreas in 3 (30%) and both in the body and tail of the pancreas in the remaining 7 (70%) patients.Patients underwent distal pancreatectomy in combination with splenectomy (n=6), total mass excision (n=2) or pancreaticoduodenectomy (n=1).Among the poor prognostic factors, only 1 patient had liver metastasis and another patient had perineural invasion.No patient had lymphovascular invasion and lymph node metastasis. Conclusion:SPN is a rare neoplasm, typically in young women.It has a slow course and can be treated with surgical resection.Patients have a good prognosis but show recurrence and metastasis.